This past week, BioDelivery Sciences International Inc. announced the successful completion of phase II trials for its BEMA Buprenorphine dental surgery pain treatment.
The Raleigh-based company has been working to use its BEMA technology for the treatment of pain following third molar extraction dental surgery. BEMA, or BioErodible MucoAdhesive, is a thin, dissolvable film that is applied to the lining of the cheek to deliver pain medication.
In the phase II trial, BDSI compared results of the different doses of BEMA Buprenorphine against a placebo and oral oxycodone. Andrew Finn, executive vice president of product development, said the results were consistent with phase I results and the doses were applicable for the relief of chronic pain. The company will continue to work to determine the effectiveness of BEMA Buprenorhine for acute pain.
“We believe that BEMA Buprenorphine has the potential to become a major player in the treatment of pain by addressing a significant unmet market need by virtue of a lower propensity for abuse and addiction compared to other opioids such as oxycodone and morphine,” said Mark A. Sirgo, president and CEO. “We are hopeful that this profile, along with our Phase 2 data, will lead to significant partnering interest.”
About BEMA Buprenorphine
BEMA Buprenorphine utilizes BDSI’s proprietary BioErodible MucoAdhesive (BEMA) drug delivery technology, which consists of a small, dissolvable, polymer film for application to the buccal mucosa (inner lining of the cheek) to deliver the opioid analgesic buprenorphine. Buprenorphine is not well absorbed orally, and is available in the U.S. to treat pain only in an injectable formulation known as Buprenex® Injectable. Pharmacokinetic studies have demonstrated the ability of the BEMA technology to deliver concentrations of buprenorphine comparable to concentrations seen with approved IV doses. A BEMA formulation potentially provides an opportunity for buprenorphine to be used in the treatment of various pain conditions in the outpatient setting. Buprenorphine is an attractive option for development given that it has demonstrated efficacy in the treatment of pain and is a Schedule III opioid, meaning there is a lower potential for abuse and addiction compared to Schedule II drugs.
According to data from Wolters Kluwer, the market for opioid analgesics for the treatment of pain totaled nearly $10 billion in 2008. BDSI believes that BEMA Buprenorphine may have the potential to offer advantages over other opioid analgesics making it a desirable partnering opportunity and a strong fit with its first product, ONSOLIS (fentanyl buccal soluble film), which was approved by FDA in July 2009 for management of breakthrough pain in opioid tolerant patients with cancer.
Source: BioDelivery Sciences International Inc.
Our mouths may encounter several dental issues over our lifetime. Most people are inclined to visit a general dentist to correct these issues. However, a cosmetic dentist can correct the dental issues we may suffer from and, sometimes, a cosmetic dentist is the better choice.
Common Dental Issues
The common dental issues that can be treated with cosmetic dentistry include:
– Discolored, stained, or yellowed teeth
– Cracked, chipped, or broken teeth
– Crowded teeth
– Gaps in teeth
– Overbite or underbite
– Crooked teeth
– Missing teeth
– Weak tooth structures
– Jaw soreness or pain
Untreated, these dental issues have the potential of causing heath problems that include diabetes and heart disease. Many health problems have oral symptoms that impact the severity of the problem. Treating your oral symptoms and dental issues with cosmetic dentistry decreases your chance of developing a health problem.
There are many people who believe that a general dentist is the only one who is trained to correct dental issues like weak tooth structures, missing teeth, or discolored teeth. General dentists are trained to correct these issues, but they do so with the focus being on your oral health. A cosmetic dentist will correct these issues while focusing on your oral health and the appearance of your smile.
Cosmetic dentists are specifically trained with advanced technology to treat your dental issues. Cosmetic dentistry technology is always evolving to create tooth restorations that perfectly match your natural teeth in size, shape, texture, and color. Cosmetic dentists usually have this technology in their dental offices to correct your dental issues in just one office visit.
Cosmetic Dentistry Treatments–
Cosmetic dentists offer a large variety of cosmetic dentistry treatments to correct these dental issues. Your cosmetic dentist will choose treatments that meet your needs to create a personalized treatment plan. The cosmetic dentistry treatments available include:
– Teeth Whitening
– Dental Implants
– Dental Crowns
– Tooth Colored Fillings
– Tooth Whitening
– Dental Bonding
– Periodontal Therapy
– TMD Treatments
– Tooth Recontouring
The information above has been provided to you by Winterholler Dentistry serving patients in Phoenix and Scottsdale, you will learn more about how cosmetic dentistry can give you a beautiful, healthy smile.
As pediatric dentists, we are constantly faced with the challenge of caring for a “hard to treat” child. Often enough parents become so frustrated and nervous about a potential “eruption” at the office, they push off dental treatment and allow simple procedures to develop into more complex issues.
Dr.Darryl Engel has been asked by many parents if there is anything they can do to make their child’s experiences at the dentist more positive. The answer is “YES”, but not all strategies will work for every child and noting your child’s unique concerns will help in getting him on the right track.
First, pick the right dentist. Pediatric dentists are trained to deal with behavior issues that many general practitioners are simply not equipped to handle. Feel free to “visit” an office and get a feel for how it runs. Many children will respond well in a more child-friendly environment. And for some kids, that little bit of warmth is all they need.
Next, be sure to understand, and agree with, some of the unique strategies the dentist may offer. As in Dr. Engel’s office, many pediatric dentists feel very comfortable treating children with Mom or Dad in the room. That extra bit of familiarity can help a nervous youngster know that everything is going to be okay. On the other hand, there are dentists who prefer to have their patients experience a one-on-one dental visit which may help solidify a child’s confidence at the office. Knowing what is best for your child can go a long way in ensuring a productive experience.
It is also important to be aware of some of the triggers of poor behavior at a dental visit. Some children suffer from a very strong gag reflex, making even routine dental visits very difficult. Similarly, many children have difficulty breathing through their nose, making it difficult to breathe during dental procedures. Children with oral-motor or sensory issues will have an even harder time at the dentist, as they will lack the confidence and control of their oral musculature to allow the dentist to get the work completed. In these situations, it is important to have a clear strategy in place. Some children need to “build-up” their dental confidence with multiple visits aimed at making him more comfortable with the procedures. For others, the use of nitrous oxide (laughing gas) can be instrumental in helping them overcome some of their sensitivities.
Lastly, remember that every child is different and there are some children for whom there is no clear cut treatment strategy. If you feel your child has no chance of getting through a dental visit, don’t give up. The more routine check-ups he experiences the more comfortable he will get with the environment and procedures. If he has a lot of cavities consider sedation as alternative to just holding him down for difficult procedures. Many pediatric dentists are specially trained to perform sedations in the office or are on-staff at local hospitals where a child can be “sleeping” through all of his dental work. This will help minimize the amount of difficult procedures in the office and will help build up his confidence with easier routine experiences.
Remember, your child is an individual, and concentrating on his specific needs will help him to overcome some of these difficult experiences.
About Darryl Engel, DMD
Dr. Engel completed his dental training at the University of Medicine and Dentistry of New Jersey.
After receiving his dental degree, he attended a two year specialty program in Pediatric Dentistry at Montefiore Medical Center in the Bronx. The acclaimed Children’s Hospital at Montefiore was a fertile training ground for Dr. Engel where he received a unique opportunity to work along side some of the best known practitioners in pediatric dentistry and medicine. Dr. Engel holds a specialty license in pediatric dentistry from New Jersey and New York. He has attained sedation certification which allows for in-office oral sedation options and is on staff at Hackensack University Medical Center. Dr. Engel lives in Northern New Jersey with his wife and three children.
KinderSmiles Pediatric Dentistry and Orthodontics has quickly become the premier provider of children’s dentistry and orthodontics for all ages in northern New Jersey. Pediatric Dentist Darryl Engel and Orthodontist Adam Schulhof have joined forces to develop a practice where patients can complete all their dental needs under one roof. KinderSmiles is located at 400 Kinderkamack Road, Oradell, NJ 07649 (201) 262-0211
As we all know, smiles are very important. It is the first thing that many people notice about a person. All of us have the ability to have these perfect smiles- so why not make it happen.
On this site- we will discuss new procedures, techniques, technologies and solutions to giving everyone the perfect smiles and faces they desire.
Please stay tuned while we begin to update the site with valuable information.